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Omicron less severe even for unvaccinated, South African study shows


/ Africa: The study, led by the National Institute of Communicable Diseases in the Western Cape region, compared 11,609 from the first three waves with 5,144 patients from the new -driven wave.

It found that 8 percent of patients were hospitalized or died within 14 days of testing positive for COVID during the Omicron wave — compared to the 16.5 percent in the first three waves.

“After adjusting for age, sex, comorbidities, and subdistrict there was a substantially reduced hazard of death in wave four compared to wave three,” the study said.

“The extent of reduction was attenuated when additionally considering prior diagnosed infections and .”

Even after prior COVID infections were taken into account, the study found there was roughly a 25 percent reduction in severe hospitalization or death with Omicron than the .

Public experts have already said Omicron appears to cause less severe disease than other variants, including Delta. But have been trying to determine whether the less severe symptoms are because people are now vaccinated or have already had COVID, or if Omicron is naturally milder.

The study, which is yet to be peer-reviewed, found about a quarter of the reduced risk of severe disease with Omicron was attributable to characteristics of the virus itself.

“In the Omicron-driven wave, severe COVID-19 outcomes were reduced mostly due to protection conferred by prior infection and/or vaccination, but intrinsically reduced virulence may account for an approximately 25 percent reduced risk of severe hospitalization or death compared to Delta,” researchers said.

Data out of South Africa, which is where the Omicron variant was first detected, has shown lower hospitalization and death rates in this latest wave.

Only 27 percent of South Africa’s population are fully vaccinated against COVID-19.

The South African study echoes one released by the Centers for Disease Control and earlier this week that Omicron poses a “substantially reduced risk” of serious illness compared to Delta.

The US-backed study found Omicron is more than 90 percent less likely to kill those infected with the virus.

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